D134

3,7-Dimethyl-1-propargylxanthine

≥98% (HPLC), powder

• 동의어(들): 3,7-Dimethyl-1-(2-propynyl)xanthine, DMPX
• 실험식(Hill 표기법): C₁₀H₁₀N₄O₂
• CAS Number: 14114-46-6
• Molecular Weight: 218.21
• MDL number: MFCD00078576
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24277754
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 15 mg/mL, clear
• SMILES string: CN1C(=O)N(CC#C)C(=O)c2c1ncn2C
• InChI: 1S/C10H10N4O2/c1-4-5-14-9(15)7-8(11-6-12(7)2)13(3)10(14)16/h1,6H,5H2,2-3H3
• InChI key: IORPOFJLSIHJOG-UHFFFAOYSA-N
• 유전자 정보: human ... ADORA2A(135), ADORA2B(136) ; rat ... Adora1(29290), Adora2a(25369)

설명

애플리케이션

3,7-Dimethyl-1-propargylxanthine (DMPX) has been used as an A₂ -adenosine receptor (AR) antagonist:

• to study its effects on potential modulation of motor output elicited by epidural spinal stimulation (ESS)
• to study the role of A_2a receptor in elevating cyclic adenosine monophosphate (cAMP) levels
• to study its effects on the cell viability of human gastric cancer cell line

생화학적/생리학적 작용

3,7-Dimethyl-1-propargylxanthine (DMPX) is a caffeine analog and A₂-selective adenosine receptor (AR) antagonist.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves