C101

8-Cyclopentyl-1,3-dipropylxanthine

solid

• 동의어(들): 1,3-Dipropyl-8-cyclopentylxanthine, DPCPX, PD 116,948
• 실험식(Hill 표기법): C₁₆H₂₄N₄O₂
• CAS Number: 102146-07-6
• Molecular Weight: 304.39
• MDL number: MFCD00055117
• UNSPSC 코드: 12352202
• PubChem Substance ID: 24277697
• NACRES: NA.77

속성

• 양식: solid
• Quality Level: 100
• 색상: white
• solubility: DMSO: >10 mg/mL; 0.1 M NaOH: 2 mg/mL; ethanol: 4 mg/mL; H₂O: insoluble
• εmax: 14,800 at 276 nm in ethanol
• SMILES string: CCCN1C(=O)N(CCC)c2nc([nH]c2C1=O)C3CCCC3
• InChI: 1S/C16H24N4O2/c1-3-9-19-14-12(15(21)20(10-4-2)16(19)22)17-13(18-14)11-7-5-6-8-11/h11H,3-10H2,1-2H3,(H,17,18)
• InChI key: FFBDFADSZUINTG-UHFFFAOYSA-N
• 유전자 정보: human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140) ; rat ... Adora1(29290), Adora2a(25369), Adora2b(29316), Adora3(25370)

설명

애플리케이션

8-Cyclopentyl-1,3-dipropylxanthine has been used as an adenosine receptor (A1AR) antagonist in macrophages and human umbilical vein endothelial cells (HUVECs). It has also been used as A1AR antagonist in MCF-7 breast cancer cell line to test its anti-cancer effect.

생화학적/생리학적 작용

8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) is a selective A1 adenosine receptor antagonist. DPCPX possesses anti-cancer functionality. It induces apoptosis in breast cancer cells and favors mRNA expression of caspases.

특징 및 장점

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves