D5294
Dilazep dihydrochloride
powder
동의어(들):
ASTA C 4898, Cormelian, N,N′-bis(3-[3,4,5-Trimethoxybenzoyloxy]propyl)homopiperazine dihydrochloride
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모든 사진(2)
About This Item
실험식(Hill 표기법):
C31H44N2O10 · 2HCl
CAS Number:
Molecular Weight:
677.61
EC Number:
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
양식
powder
Quality Level
색상
white
solubility
H2O: 10 mg/mL
저장 온도
2-8°C
SMILES string
Cl[H].Cl[H].COc1cc(cc(OC)c1OC)C(=O)OCCCN2CCCN(CCCOC(=O)c3cc(OC)c(OC)c(OC)c3)CC2
InChI
1S/C31H44N2O10.2ClH/c1-36-24-18-22(19-25(37-2)28(24)40-5)30(34)42-16-8-12-32-10-7-11-33(15-14-32)13-9-17-43-31(35)23-20-26(38-3)29(41-6)27(21-23)39-4;;/h18-21H,7-17H2,1-6H3;2*1H
InChI key
VILIWRRWAWKXRW-UHFFFAOYSA-N
유전자 정보
human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
일반 설명
Dilazep comprises central cyclic diamine and phenyl rings connected via alkyl linkers.
애플리케이션
Dilazep dihydrochloride has been used in estrogen receptor (ERα) antagonistic assay. It has also been used as an equilibrative nucleoside transporter inhibitor (ENT 1 and 2) in cancer cell lines.
생화학적/생리학적 작용
Dilazep is a equilibrative nucleoside transporter 1 (ENTs) inhibitor. It is an antianginal drug and an effective coronary vasodilator. Dilazep elicits anti-albuminuric effects and is an anti-platelet agent. It is a potent adenosine uptake inhibitor and suppresses effects of ischemia.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
S M Delaney et al.
The Journal of pharmacology and experimental therapeutics, 285(2), 568-572 (1998-05-15)
Selective inhibitors of adenosine production, degradation and transport were used to potentiate in vivo levels of adenosine and to determine the source of both basal and N-methyl-D-aspartate (NMDA)-induced increases in levels of endogenous adenosine in vivo. Male Sprague-Dawley rats receiving
H Deguchi et al.
Blood, 90(6), 2345-2356 (1997-10-06)
Dilazep, an antiplatelet agent, is generally used as an antithrombotic drug in clinical practice. Dilazep is also known to exert cytoprotective and antioxidant effects on endothelial cells. However, its effect on the endothelial or monocyte procoagulant activity is unknown. In
Dilazep analogues for the study of equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2)
Playa H, et al.
Bioorganic & medicinal chemistry letters, 24(24), 5801-5804 (2014)
M Griffiths et al.
The Biochemical journal, 328 ( Pt 3), 739-743 (1998-02-07)
Mammalian equilibrative nucleoside transporters are typically divided into two classes, es and ei, based on their sensitivity or resistance respectively to inhibition by nitrobenzylthioinosine (NBMPR). Previously, we have reported the isolation of a cDNA clone encoding a prototypic es-type transporter
Yukihiko Kawasaki et al.
Pediatrics international : official journal of the Japan Pediatric Society, 57(4), 650-655 (2015-01-24)
We examined the epidemiology, clinical manifestations, and prognosis of pediatric systemic lupus erythematosus (SLE) in Fukushima Prefecture, Japan over a 35 year period. We collected the medical records of 37 patients diagnosed with SLE between 1977 and 2013. These children
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