E8755

Erythromycin ethyl succinate

• 실험식(Hill 표기법): C₄₃H₇₅NO₁₆
• CAS Number: 1264-62-6
• Molecular Weight: 862.05
• EC Number: 215-033-8
• MDL number: MFCD00084692
• UNSPSC 코드: 51282328
• PubChem Substance ID: 24894684
• NACRES: NA.85

속성

• 생물학적 소스: microbial
• 양식: solid
• 효능: ≥780 μg per mg
• 색상: white
• solubility: ethanol: 50 mg/mL
• 항생제 활성 스펙트럼: Gram-positive bacteria
• 동작 모드: protein synthesis | interferes
• SMILES string: CCOC(=O)CCC(=O)OC1C(CC(C)OC1OC2C(C)C(OC3CC(C)(OC)C(O)C(C)O3)C(C)C(=O)OC(CC)C(C)(O)C(O)C(C)C(=O)C(C)CC2(C)O)N(C)C
• InChI: 1S/C43H75NO16/c1-15-29-43(11,52)36(48)24(5)33(47)22(3)20-41(9,51)38(25(6)34(26(7)39(50)57-29)59-32-21-42(10,53-14)37(49)27(8)56-32)60-40-35(28(44(12)13)19-23(4)55-40)58-31(46)18-17-30(45)54-16-2/h22-29,32,34-38,40,48-49,51-52H,15-21H2,1-14H3
• InChI key: NSYZCCDSJNWWJL-UHFFFAOYSA-N

설명

일반 설명

Chemical structure: macrolide

애플리케이션

Erythromycin ethyl succinate is used to study erythromycin-resistant Streptococcus pyogenes and Streptococcus pneumoniae. It has been used to study down-regulation of motilin receptors on rabbit colon myocytes and lethal mutations in outer membrane genes omsA and firA in Salmonella typhimurium.

생화학적/생리학적 작용

Erythromycin inhibits protein synthesis (elongation) at the level of transpeptidation (aminoacyl translocation A-site to P-site) by binding to the 50s subunit of the bacterial 70s rRNA complex.

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H317,H334
• 예방조치 성명서: P261 - P280 - P342 + P311
• Hazard Classifications: Resp. Sens. 1 - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves