E9386

5-Ethyl-2′-deoxyuridine

• 동의어(들): EUdR, Edoxudine
• 실험식(Hill 표기법): C₁₁H₁₆N₂O₅
• CAS Number: 15176-29-1
• Molecular Weight: 256.26
• EC Number: 239-226-1
• MDL number: MFCD00079191
• UNSPSC 코드: 41106305
• PubChem Substance ID: 24894696
• NACRES: NA.51

속성

• 생물학적 소스: synthetic (organic)
• Quality Level: 200
• 분석: ≥95% (HPLC)
• 양식: powder
• solubility: water: 50 mg/mL, clear, colorless to yellow
• 저장 온도: −20°C
• SMILES string: CCC1=CN(C2CC(O)C(CO)O2)C(=O)NC1=O
• InChI: 1S/C11H16N2O5/c1-2-6-4-13(11(17)12-10(6)16)9-3-7(15)8(5-14)18-9/h4,7-9,14-15H,2-3,5H2,1H3,(H,12,16,17)
• InChI key: XACKNLSZYYIACO-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

5-Ethyl-2′-deoxyuridine (EUdR) is used as a 5-fluorouracil (FU) modulator. EtdUrd may be used to enhance the therapeutic index of 5-FU by reducing the catabolism, prolonging the plasma and intratumoral concentrations of 5-FU, and offering protection to normal organs by increasing the endogenous uridine levels.

5-Ethyl-2′-deoxyuridine is an analog of pyrimidine, uridine. It is an effective antiviral agent and inhibits cell division in leukemic tumor cells. 5-Ethyl-2′-deoxyuridine interacts with 2′-deoxycytidine phosphate (dCTP) biosynthesis pathway to elicit antiproliferative effects.

결합

Homolog of thymidine

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)