E9531

Ebastine

≥98% (HPLC), solid

• 동의어(들): 1-[4-(1,1-Dimethylethyl)phenyl]-4-[4-(diphenylmethoxy)-1-piperidinyl]-1-butanone
• 실험식(Hill 표기법): C₃₂H₃₉NO₂
• CAS Number: 90729-43-4
• Molecular Weight: 469.66
• MDL number: MFCD00865661
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329799086
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 색상: white
• solubility: DMSO: >10 mg/mL; H₂O: insoluble
• 저장 온도: room temp
• SMILES string: CC(C)(C)c1ccc(cc1)C(=O)CCCN2CCC(CC2)OC(c3ccccc3)c4ccccc4
• InChI: 1S/C32H39NO2/c1-32(2,3)28-18-16-25(17-19-28)30(34)15-10-22-33-23-20-29(21-24-33)35-31(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-9,11-14,16-19,29,31H,10,15,20-24H2,1-3H3
• InChI key: MJJALKDDGIKVBE-UHFFFAOYSA-N

설명

일반 설명

Ebastine is metabolised by cytochrome P450 3A (CYP3A4) to carebastine. It is used to treat allergic rhinitis and chronic idiopathic urticaria.

애플리케이션

Ebastine has been used as a cationic amphiphilic drug (CAD) in sensitizing cancerous cells to chemotherapy and revert multidrug resistance.

생화학적/생리학적 작용

Ebastine is a non-sedating histamine H₁ receptor antagonist, which inhibits allergen-induced bronchospasm in conscious guinea pigs. Unlike other compounds in this category, ebastine does not prolong the QT interval at up to five times the recommended therapeutic dose.

Ebastine is a non-sedating histamine H₁ receptor antagonist.

특징 및 장점

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)