F5013

5-Fluoroorotic acid hydrate

≥98%

• 동의어(들): 2,6-Dihydroxy-5-fluoropyrimidine-4-carboxylic acid, 5-Fluorouracil-4-carboxylic acid
• 실험식(Hill 표기법): C₅H₃FN₂O₄ · xH₂O
• CAS Number: 207291-81-4
• Molecular Weight: 174.09 (anhydrous basis)
• EC Number: 211-876-0
• MDL number: MFCD00150658
• UNSPSC 코드: 12352204
• PubChem Substance ID: 24894877
• NACRES: NA.32

속성

• 생물학적 소스: synthetic
• 분석: ≥98%
• 양식: powder
• 기술: cell culture | plant: suitable
• mp: 278 °C (dec.) (lit.)
• solubility: 4 M NH₄OH: 50 mg/mL, clear, colorless to light yellow
• 저장 온도: −20°C
• SMILES string: OC(C(NC(N1)=O)=C(F)C1=O)=O.[H]O[H]
• InChI: 1S/C5H3FN2O4.H2O/c6-1-2(4(10)11)7-5(12)8-3(1)9;/h(H,10,11)(H2,7,8,9,12);1H2
• InChI key: LODRRYMGPWQCTR-UHFFFAOYSA-N

설명

애플리케이션

5-Fluoroorotic acid hydrate has also been used as a counter-selection agent to screen L. lactis (multi) peptidase knockout mutants and C. albicans. It has been used in synthesis of 5-fluoroorotidine 5′-monophosphate (FOMP).

Useful in the selection of orotidine-5′-phosphate decarboxylase mutants of Saccharomyces cerevisiae.

생화학적/생리학적 작용

5-Fluoroorotic acid is a selective inhibitor of rRNA synthesis in mammals.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302,H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves