G3295

GW0742

≥98% (HPLC)

• 동의어(들): 4-[2-(3-Fluoro-4-trifluoromethyl-phenyl)-4-methyl-thiazol-5-ylmethylsulfanyl]- 2-methyl-phenoxy}-acetic acid
• 실험식(Hill 표기법): C₂₁H₁₇F₄NO₃S₂
• CAS Number: 317318-84-6
• Molecular Weight: 471.49
• MDL number: MFCD07369423
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24895123
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white
• mp: 134.5-135.5 °C
• solubility: DMSO: >5 mg/mL; H₂O: insoluble
• 주관자: GlaxoSmithKline
• 저장 온도: 2-8°C
• SMILES string: Cc1cc(SCc2sc(nc2C)-c3ccc(c(F)c3)C(F)(F)F)ccc1OCC(O)=O
• InChI: 1S/C21H17F4NO3S2/c1-11-7-14(4-6-17(11)29-9-19(27)28)30-10-18-12(2)26-20(31-18)13-3-5-15(16(22)8-13)21(23,24)25/h3-8H,9-10H2,1-2H3,(H,27,28)
• InChI key: HWVNEWGKWRGSRK-UHFFFAOYSA-N
• 유전자 정보: human ... PPARA(5465), PPARD(5467), PPARG(5468)

설명

생화학적/생리학적 작용

GW0742 is a highly selective PPARδ agonist. EC₅₀ = 1 nM vs 1 μM and 2 μM for PPARα and PPARγ, respectively.

특징 및 장점

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

법적 정보

Sold for research purposes under agreement from Glaxo­Smith­Kline

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)