T2573

Troglitazone

≥98% (HPLC), powder, PPARγ agonist

• 동의어(들): (±)-5-[4-[(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione, CS-045
• 실험식(Hill 표기법): C₂₄H₂₇NO₅S
• CAS Number: 97322-87-7
• Molecular Weight: 441.54
• MDL number: MFCD00878416
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24724629
• NACRES: NA.77

속성

• Product Name: Troglitazone, ≥98% (HPLC)
• Quality Level: 200
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to off-white
• solubility: DMSO: 20 mg/mL
• SMILES string: Cc1c(C)c2OC(C)(CCc2c(C)c1O)COc3ccc(CC4SC(=O)NC4=O)cc3
• InChI: 1S/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,9-12H2,1-4H3,(H,25,27,28)
• InChI key: GXPHKUHSUJUWKP-UHFFFAOYSA-N
• 유전자 정보: human ... PPARA(5465), PPARG(5468)

설명

일반 설명

Troglitazone is used to treat type 2 diabetes. It is associated with liver injury. Troglitazone functions as an inducer of cytochrome3A.

애플리케이션

Troglitazone has been used as a reagent in adipocyte differentiation medium.

생화학적/생리학적 작용

PPARγ agonist; anti-diabetic thiazolidinedione (TZD) with anti-inflammatory and anti-tumor activity; induces apoptosis via a p53 pathway.

특징 및 장점

This compound is featured on the Nuclear Receptors (PPARs) and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

제조 메모

Studies using troglitazone have reported that it can increase AMP-activated protein kinase (pAMPK) and phosphorylated acetyl-CoA carboxylase in isolated rat extensor digitorum longus muscles¹. Furthermore, analysis of troglitazone-mediated autophagy is reported to correlate with the stimulation of AMPK α².

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)