H2042

Histone H2A human

• 동의어(들): Histone, Human
• CAS Number: 1523001-32-2
• UNSPSC 코드: 12352202
• NACRES: NA.25

속성

• 생물학적 소스: human
• Quality Level: 200
• 재조합: expressed in E. coli
• 양식: liquid
• 농도: 1 mg/mL
• UniProt 수납 번호: Q16777
• 응용 분야: cell analysis
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... H2AC20(8338)

설명

일반 설명

Histones are highly basic chromatin proteins. They tightly pack and organize eukaryotic DNA to form nucleosomes. A nucleosome comprises an octameric core histone made of a tetramer of histones H3 and H4 with two dimers of histones H2A and H2B. The 147 DNA base pairs are wrapped around the histone complex. H2A consists of a C-terminal tail extending out of the nucleosome core particle.

애플리케이션

Histone H2A human has been used as a neutrophil extracellular trap (NET) to study its effects on the membrane integrity and viability of macrophages (MFS) and dendritic cells (DCS). It has also been used in far-western blot analysis for protein identification.

생화학적/생리학적 작용

Histones modulate the accessibility of DNA during transcription, DNA replication, DNA repair, and recombination. N and C terminal tails undergo post-translational modifications (PTMs) altering DNA wrapping and chromatin regulation.

물리적 형태

Supplied in 20 mM Na₃PO₄, pH 7.0, 0.3 M NaCl and 1 mM EDTA

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H350
• 예방조치 성명서: P201 - P308 + P313
• Hazard Classifications: Carc. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable