H6541

Oncostatin M human

OSM, recombinant, expressed in HEK 293 cells, HumanKine^®, suitable for cell culture

• 동의어(들): OSM
• CAS Number: 106956-32-5
• MDL number: MFCD00166731
• UNSPSC 코드: 12352202
• NACRES: NA.77

속성

• 생물학적 소스: human
• Quality Level: 100
• 재조합: expressed in HEK 293 cells
• 분석: ≥95% (SDS-PAGE)
• 양식: lyophilized powder
• 효능: ≤0.1-1.5 ng/mL EC₅₀
• 품질: endotoxin tested
• 분자량: dimer 30 kDa (glycosylated)
• 포장: pkg of 5X10 μg; pkg of 10 μg
• 기술: cell culture | mammalian: suitable
• 불순물: ≤1 EU/μg
• UniProt 수납 번호: P13725
• 저장 온도: −20°C
• 유전자 정보: human ... OSM(5008)

설명

생화학적/생리학적 작용

Oncostatin M (OSM), LIF, G-CSF, IL-6, and CNTF are structurally related members of the same cytokine family sharing similarities in their primary amino acid sequences, predicted secondary structure, and receptor components. OSM is a growth-regulating cytokine, affecting a number of tumor and normal cells. This material was first identified by its ability to inhibit the growth of A375 melanoma cells and other human tumor cells, but not inhibit the growth of normal human fibroblasts. It acts synergistically with TGF β1 to inhibit the proliferation of tumor cells like A375 melanoma cells. It induces an increase in LDL receptor expression and LDL uptake by hepatoma cells. OSM activates synovial fibroblast-like cells to produce urokinase type plasminogen activator. OSM is secreted by macrophages and activated T lymphocytes.

물리적 형태

Lyophilized from a 0.2 μm filtered solution of 1x PBS.

분석 메모

The activity was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells (humanerythroleukemic indicator cell line)

법적 정보

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable