O1637

Oncostatin M from mouse

BioReagent, ≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

• 동의어(들): OSM
• CAS Number: 106956-32-5
• MDL number: MFCD01094784
• UNSPSC 코드: 12352202
• NACRES: NA.32

속성

• 생물학적 소스: mouse
• Quality Level: 200
• 재조합: expressed in E. coli
• 제품 라인: BioReagent
• 분석: ≥97% (SDS-PAGE)
• 양식: lyophilized powder
• 효능: 0.25-1 ng/mL EC₅₀
• 분자량: 21 kDa
• 포장: pkg of 25 μg
• 기술: cell culture | mammalian: suitable
• 불순물: endotoxin, tested
• UniProt 수납 번호: P53347
• 저장 온도: −20°C
• 유전자 정보: mouse ... Osm(18413)

설명

애플리케이션

Oncostatin M from mouse has been used in the preparation of culture medium for primary culture of mouse fetal hepatoblasts (MFHs).

생화학적/생리학적 작용

Oncostatin M, LIF, G-CSF, IL-6, and ciliary neurotrophic factor (CNTF) are structurally related members of the same cytokine family sharing similarities in their primary amino acid sequences, predicted secondary structure, and receptor components. Oncostatin M is a growth-regulating cytokine, affecting a number of tumor and normal cells. This material was first identified by its ability to inhibit the growth of A375 melanoma cells and other human tumor cells, but not inhibit the growth of normal human fibroblasts. It acts synergistically with TGF β1 to inhibit the proliferation of tumor cells like A375 melanoma cells. It induces an increase in LDL receptor expression and LDL uptake by hepatoma cells. OSM activates synovial fibroblast-like cells to produce urokinase type plasminogen activator. Oncostatin M is secreted by macrophages and activated T lymphocytes.

물리적 형태

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 1.25 mg bovine serum albumin.

분석 메모

The biological activity of recombinant mouse OSM was measured by its ability to stimulate ³H-thymidine incorporation in quiescent NIH/3T3 cells.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)