I5273

Interleukin-5 human

recombinant, expressed in baculovirus infected Sf21 cells, ≥97% (SDS-PAGE), lyophilized powder, suitable for cell culture

• 동의어(들): IL-5
• MDL number: MFCD00163946
• UNSPSC 코드: 12352202
• NACRES: NA.32

속성

• 생물학적 소스: human
• Quality Level: 200
• 재조합: expressed in baculovirus infected Sf21 cells
• 분석: ≥97% (SDS-PAGE)
• 양식: lyophilized powder
• 효능: 0.1-0.5 ng/mL EC₅₀
• 분자량: 32-34 kDa
• 포장: pkg of 5 μg
• 농도: 0.5-10 ng/mL
• 기술: cell culture | mammalian: suitable
• 불순물: endotoxin, tested
• UniProt 수납 번호: P05113
• 저장 온도: −20°C
• 유전자 정보: human ... IL5(3567)

설명

생화학적/생리학적 작용

IL-5 (interleukin-5) is a maturation and differentiation factor for eosinophils. Thus, it is associated with allergy and related disorders. IL-5 association with its receptor causes activation of MEK/ERK (mitogen activated protein kinase kinase/extracellular-regulated kinase), p38 MAPK (mitogen activated protein kinase) and JAK/STAT (Janus kinase/signal transducer and activator of transcription) pathways.

Interleukin-5 is a product of activated T lymphocytes and exhibits activity on eosinophils, B cells and thymocytes. Synonyms or biological activities attributed to IL-5 include: EDF (eosinophil differentiating factor), BCGF-II (B cell growth factor-II), TRF (T cell replacing factor), IgA-EF (IgA enhancing factor) and EO-CSF (eosinophil colony stimulating factor). Natural IL-5 is a 45-50 kDa dimeric glycoprotein, although glycosylation is not required for activity. Human and mouse IL-5 exhibit homology at the nucleotide and amino acid levels and show species cross-reactivity.

물리적 형태

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.1 mg bovine serum albumin.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)