I4269

IL-4 human

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

• 동의어(들): IL-4, Interleukin-4 human, hIL-4
• MDL number: MFCD00151705
• UNSPSC 코드: 12352202
• NACRES: NA.77

속성

• Product Name: Interleukin-4 human, IL-4, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
• 생물학적 소스: human
• Quality Level: 200
• 재조합: expressed in E. coli
• 분석: ≥98% (SDS-PAGE)
• 양식: lyophilized powder
• 효능: ≤0.400 ng/mL EC₅₀
• 품질: endotoxin tested
• 분자량: 14.9 kDa (containing 129 amino acid residues)
• 포장: pkg of 5 and 50 μg
• 기술: cell culture | mammalian: suitable
• 불순물: ≤1.000 EU/μg
• 색상: white
• UniProt 수납 번호: P05112
• 저장 온도: −20°C
• 유전자 정보: human ... IL4(3565) ; mouse ... IL4(3565)

설명

일반 설명

Interleukin-4 (IL-4) is a pleiotropic cytokine that regulates diverse T and B cell responses including differentiation of naive T cells into the TH2 phenotype, promoting B cell proliferation, antibody isotype switching, and expression of other TH2 cytokines including IL-5 and IL-9.^1,2 IL-4 plays a critical role in the development of allergic inflammation and asthma.³

IL-4 binds to two distinct receptors; the type I receptor, a heterodimer consisting of the IL-4Rα chain and the common gamma chain, γc, and the type II receptor, a heterodimer of IL-4Rα and IL-13Rα1.⁴

Naturally occurring IL-4 has a molecular mass of 12-20 kDa. Recombinant human IL-4 is a 14.9 kDa protein containing 129 amino acid residues. Human and mouse IL-4 share a 50% amino acid sequence homology, but their biological actions are species-specific.⁵

애플리케이션

Lymphokine with profound effects on the growth and differentiation of immunologically competent cells, inhibits VEGF-induced and βFGF-induced angiogenesis.

물리적 형태

Lyophilized from a sterile filtered solution.

분석 메모

The biological activity is measured by the dose-dependent stimulation of the proliferation of human TF-1 cells.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable