L9919

LY2033298

≥98% (HPLC)

• 동의어(들): 3-Amino-5-chloro-N-cyclopropyl-6-methoxy-4-methyl-thieno[2,3-b]pyridine-2-carboxamide
• 실험식(Hill 표기법): C₁₃H₁₄ClN₃O₂S
• CAS Number: 886047-13-8
• Molecular Weight: 311.79
• MDL number: MFCD12912423
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329817677
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 저장 조건: desiccated
• 색상: off-white to tan
• solubility: DMSO: >20 mg/mL
• 주관자: Eli Lilly
• 저장 온도: −20°C
• SMILES string: COc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl
• InChI: 1S/C13H14ClN3O2S/c1-5-7-9(15)10(11(18)16-6-3-4-6)20-13(7)17-12(19-2)8(5)14/h6H,3-4,15H2,1-2H3,(H,16,18)
• InChI key: CTEGQKDJTBWFHW-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

LY2033298 is a positive allosteric modulator of muscarinic M4 receptor.

LY2033298 is a robust allosteric potentiator that is highly selective for the human M4 muscarinic acetylcholine receptor subtype. LY2033298 potentiates ACh-M4 binding, with no effect at M1/3/5 receptors. LY2033298 can also bind to the M ACh receptor, and mediate either positive or negative allosteric effects depending on the ligand used to probe receptor activity.

특징 및 장점

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H334
• 예방조치 성명서: P261 - P284 - P501
• Hazard Classifications: Resp. Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable