M1547

Metronidazole

BioXtra

• 동의어(들): 2-Methyl-5-nitroimidazole-1-ethanol
• 실험식(Hill 표기법): C₆H₉N₃O₃
• CAS Number: 443-48-1
• Molecular Weight: 171.15
• Beilstein: 611683
• EC Number: 207-136-1
• MDL number: MFCD00009750
• UNSPSC 코드: 51282808
• PubChem Substance ID: 24896667
• NACRES: NA.76

속성

• 제품 라인: BioXtra
• Quality Level: 200
• 불순물: ≤0.2% Total Impurities
• 무기 잔류물: ≤0.1%
• 색상: white to light yellow
• mp: 159-161 °C (lit.)
• solubility: acetic acid: 0.1 M, clear, colorless to yellow
• 음이온 미량물: chloride (Cl^-): ≤0.05%; sulfate (SO₄^2-): ≤0.05%
• 양이온 미량물: Al: ≤0.0005%; Ca: ≤0.005%; Cu: ≤0.0005%; Fe: ≤0.0005%; K: ≤0.005%; Mg: ≤0.0005%; Na: ≤0.01%; Pb: ≤0.001%; Zn: ≤0.0005%
• 항생제 활성 스펙트럼: Gram-negative bacteria; parasites
• 동작 모드: DNA synthesis | interferes
• 저장 온도: 2-8°C
• SMILES string: CC1=NC=C([N+]([O-])=O)N1CCO
• InChI: 1S/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3
• InChI key: VAOCPAMSLUNLGC-UHFFFAOYSA-N

설명

일반 설명

Chemical structure: imidazole

애플리케이션

Metronidazole is used to study DNA damage and repair and has been found to induce the gene transfer agent VSH-1 in Brachyspira hyodysenteriae. It is commonly used for treatment of periodontitis and is used in bioavailability studies.

생화학적/생리학적 작용

Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its active form. Reduced metronidazole covalently binds to DNA which disrupts its helical structure, induces DNA strand breaks and inhibits bacterial nucleic acid synthesis. Bacterial cell death results.

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H340,H350,H373
• 예방조치 성명서: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Carc. 1B - Muta. 1B - STOT RE 2
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves