M1559

Moxonidine hydrochloride

≥98%

• 동의어(들): 4-Chloro-6-methoxy-2-methyl-5-(2-imidazolin-2-yl)aminopyrimidine hydrochloride, BDF-5895
• 실험식(Hill 표기법): C₉H₁₂ClN₅O · HCl
• CAS Number: 75438-58-3
• Molecular Weight: 278.14
• MDL number: MFCD06795643
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278537
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98%
• 주관자: Solvay
• SMILES string: Cl.COc1nc(C)nc(Cl)c1NC2=NCCN2
• InChI: 1S/C9H12ClN5O.ClH/c1-5-13-7(10)6(8(14-5)16-2)15-9-11-3-4-12-9;/h3-4H2,1-2H3,(H2,11,12,15);1H
• InChI key: ZZPAWQYZQVUVHX-UHFFFAOYSA-N
• 유전자 정보: human ... ADRA2A(150), ADRA2B(151), ADRA2C(152), NISCH(11188)

설명

애플리케이션

Moxonidine hydrochloride has been used:

• as a standard to study its blood-brain barrier (BBB) permeability in porcine brain lipid extract by parallel artificial membrane permeability assay (PAMPA) method
• as a standard to study the chromatographic behavior and lipophilicity by reversed-phase thin-layer chromatography (RP-TLC)
• as an imidazoline I1 receptor agonist to study its effects on excitatory inputs in airway vagal preganglionic neuron (AVPN)

생화학적/생리학적 작용

Moxonidine is a selective high-affinity imidazoline I1-receptor agonist and a selectively low-affinity α2-adrenoceptor agonist. It exhibits anti-hypertensive properties by reducing blood pressure efficiently. Moxonidine also exhibits spinal analgesic activity through the α_2C-adrenoceptor component.

특징 및 장점

This compound is featured on the Imidazoline Binding Sites page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Solvay. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)