G1043

Guanfacine hydrochloride

≥98% (HPLC)

• 동의어(들): N (Aminoiminomethyl)-2,6-dichlorobenzeneacetamide
• 실험식(Hill 표기법): C₉H₉Cl₂N₃O · HCl
• CAS Number: 29110-48-3
• Molecular Weight: 282.55
• MDL number: MFCD00798230
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278452
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 색상: white
• solubility: H₂O: soluble 12 mg/mL at 60 °C
• 주관자: Promius
• SMILES string: Cl.NC(=N)NC(=O)Cc1c(Cl)cccc1Cl
• InChI: 1S/C9H9Cl2N3O.ClH/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13;/h1-3H,4H2,(H4,12,13,14,15);1H
• InChI key: DGFYECXYGUIODH-UHFFFAOYSA-N
• 유전자 정보: human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

설명

애플리케이션

Guanfacine hydrochloride has been used as an α2A adrenoceptor agonist to test its protective effect on hypobaric hypoxia (HH) and in rat brain to measure blood oxygenation level dependent (BOLD) response.

생화학적/생리학적 작용

Guanfacine stimulates the brain postsynaptic α2 adrenergic receptor (AR) and mediates the prefrontal cortical (PFC) neuronal regulation and strengthens their network. Guanfacine improves the density of neuronal dendrites and is useful in treating neuropsychiatric disorders. It modulates the synaptic and cytoskeletal proteins expression in prefrontal cortical (PFC) neurons and may improve hypobaric hypoxia (HH) induced PFC dysfunctions. Guanfacine enhances cognitive function and is recommended for attention deficit hyperactivity disorder (ADHD) therapy.

α-2 noradrenergic receptor agonist.

특징 및 장점

This compound was developed by Promius. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)