M182

MDL-12,330A hydrochloride

≥98% (HPLC), powder

• 동의어(들): cis-N-(2-Phenylcyclopentyl)-azacyclotridec-1-en-2-amine hydrochloride
• 실험식(Hill 표기법): C₂₃H₃₆N₂ · HCl
• CAS Number: 40297-09-4
• Molecular Weight: 377.01
• MDL number: MFCD00210204
• UNSPSC 코드: 41106305
• PubChem Substance ID: 24896696
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• 색상: white to off-white
• solubility: DMSO: >20 mg/mL
• 저장 온도: 2-8°C
• SMILES string: Cl[H].C1CCCCCN=C(CCCCC1)N[C@H]2CCC[C@H]2c3ccccc3
• InChI: 1S/C23H36N2.ClH/c1-2-4-6-11-18-23(24-19-12-7-5-3-1)25-22-17-13-16-21(22)20-14-9-8-10-15-20;/h8-10,14-15,21-22H,1-7,11-13,16-19H2,(H,24,25);1H/t21-,22-;/m0./s1
• InChI key: CKOPQUCSDBVAQG-VROPFNGYSA-N

설명

애플리케이션

MDL-12,330A hydrochloride has been used as an inhibitor of adenylyl cyclase to block cyclic AMP signaling in mesenchymal stem/stromal cells (MSC). It has also been used as an adenylyl cyclase blocker to test its effect on the locomotor activity based on tail suspension test (TST) in mice.

생화학적/생리학적 작용

Adenylyl cyclase inhibitor.

MDL-12,330A is a cycloalkyl lactamimide that acts as a voltage-gated potassium channel blocker (KV) leading to extension of action potential duration (APD) and favoring insulin secretion. It also blocks calcium (Ca²⁺) entry.

특징 및 장점

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Adenylyl cyclases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)