M2537

Mevastatin

≥98% (HPLC), powder or crystals

• 동의어(들): Compactin, ML-236B
• 실험식(Hill 표기법): C₂₃H₃₄O₅
• CAS Number: 73573-88-3
• Molecular Weight: 390.51
• Beilstein: 1269441
• MDL number: MFCD05662341
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278540
• NACRES: NA.77

속성

• Quality Level: 200
• 분석: ≥98% (HPLC)
• 양식: powder or crystals
• 색상: white to light yellow
• mp: 151 °C
• solubility: ethanol: 25-26 mg/mL, clear, colorless
• 항생제 활성 스펙트럼: neoplastics
• 동작 모드: enzyme | inhibits
• 주관자: Daiichi-Sankyo
• 저장 온도: 2-8°C
• SMILES string: [H][C@]12[C@H](CCC=C1C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)OC(=O)[C@@H](C)CC
• InChI: 1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22-/m0/s1
• InChI key: AJLFOPYRIVGYMJ-INTXDZFKSA-N
• 유전자 정보: human ... HMGCL(3155), HMGCR(3156) ; rat ... Hmgcr(25675)

설명

일반 설명

Chemical structure: statin

Mevastatin is a polyketide that belongs to the class of statins. It contains a hydroxy-hexahydronaphthalene ring.

애플리케이션

Mevastatin has been used:

• to analyze its effects on chronic lymphocytic leukemia (CLL) cells by cytotoxic assay
• as a prenylation inhibitor to analyze its effects on human embryonic kidney (HEK) cells transfected with K-Ras
• as a statin agent to study its anti-cancer effect on human breast cancer cells and glioblastoma in vitro

생화학적/생리학적 작용

Mevastatin is a selective inhibitor of 3-hydroxy 3-methyl glutaryl coenzyme(A) reductase (HMG-CoA reductase), a major enzyme involved in cholesterol synthesis. It acts as a cholesterol-lowering agent. Mevastatin is obtained from various species of fungi. It acts as an antiresorptive agent and has therapeutic effects to treat osteoporosis. Mevastatin inhibits bone resorption by triggering osteoclast apoptosis. It is also involved in the inhibition of prenylation of proteins such as Ras. Mevastatin increases endothelial nitric oxide synthase (eNOS) mRNA and protein levels by blocking the geranylgeranylation of transcription factor Rho.

특징 및 장점

This compound was developed by Daiichi-Sankyo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)