M4910

1-Methylhistamine dihydrochloride

≥98% (TLC), powder

• 동의어(들): 1-Methyl-4-(β-aminoethyl)imidazole dihydrochloride
• 실험식(Hill 표기법): C₆H₁₁N₃ · 2HCl
• CAS Number: 6481-48-7
• Molecular Weight: 198.09
• MDL number: MFCD00037000
• UNSPSC 코드: 12352204
• PubChem Substance ID: 24277805
• NACRES: NA.32

속성

• Product Name: 1-Methylhistamine dihydrochloride, ≥98% (TLC), powder
• Quality Level: 200
• 분석: ≥98% (TLC)
• 양식: powder
• solubility: water: 49.00-51.00 mg/mL, clear, colorless to faintly yellow
• 저장 온도: 2-8°C
• SMILES string: Cl[H].Cl[H].Cn1cnc(CCN)c1
• InChI: 1S/C6H11N3.2ClH/c1-9-4-6(2-3-7)8-5-9;;/h4-5H,2-3,7H2,1H3;2*1H
• InChI key: AGXVEALMQHTMSW-UHFFFAOYSA-N
• 유전자 정보: human ... HRH1(3269), HRH2(3274), HRH3(11255), HRH4(59340)

설명

애플리케이션

1-Methylhistamine dihydrochloride has been used as a standard in the evaluation of histamine levels in aqueous humor of glaucoma patients by liquid chromatography. It has also been used as a substrate to determine amine oxidase activity.

생화학적/생리학적 작용

1-Methylhistamine is present in the brain and is a metabolite of histamine that is metabolized by histamine N-methyltransferase. It acts as a biomarker for histaminergic system activity in the cerebrospinal fluid of patients suffering from Alzheimer′s disease (AD), hypersomnia, and other neurological conditions.

Major metabolite of histamine by histamine N-methyltransferase.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves