H7125

Histamine

≥97% (TLC), powder, H₁ and H₂ histamine receptor agonist

• 동의어(들): 2-(4-Imidazolyl)ethylamine
• 실험식(Hill 표기법): C₅H₉N₃
• CAS Number: 51-45-6
• Molecular Weight: 111.15
• Beilstein: 2012
• EC Number: 200-100-6
• MDL number: MFCD00005210
• UNSPSC 코드: 12352116
• eCl@ss: 32160406
• PubChem Substance ID: 24895783
• NACRES: NA.77

속성

• Product Name: Histamine, ≥97.0%
• Quality Level: 200
• 분석: ≥97.0%
• bp: 167 °C/0.8 mmHg (lit.)
• mp: 83-84 °C (lit.)
• 저장 온도: −20°C
• SMILES string: NCCc1c[nH]cn1
• InChI: 1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
• InChI key: NTYJJOPFIAHURM-UHFFFAOYSA-N
• 유전자 정보: human ... CA1(759), CA2(760), HRH1(3269), HRH2(3274), HRH3(11255), HRH4(59340) ; rat ... Hrh1(24448), Hrh3(85268)

설명

일반 설명

Histamine is a neurotransmitter produced by neurons of the posterior hypothalamus. In the brain, histamine is predominantly present in the gray matter.

애플리케이션

Histamine has been used:

• to stimulate regulated cellular secretion
• in reaction mixture to activate blood for assaying thrombin (factor iia) activity by fluorimetry
• to fill the luminal side of the chamber to investigate its effects on the TJ-related barrier and the expression of TJ (tight junction) markers in the vocal fold epithelium

생화학적/생리학적 작용

Endogenous H₁ and H₂ histamine receptor agonist; H₁ activation mobilizes Ca²⁺; H₂ activation stimulates adenylate cyclase activity in neurons; activates nitric oxide synthetase; potent vasodilator.

Endogenous H₁ and H₂ histamine receptor agonist; activates nitric oxide synthetase; potent vasodilator.

Histamine participates in innate and acquired immune response, mediating allergy and inflammation. It helps in intestinal muscle contraction. During anaphylactic shock histamine causes bronchial constriction. Histamine is also involved in gastric acid secretion, epithelial and endothelial barrier control.

안전성 정보

• 픽토그램: GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H301,H315,H317,H319,H334,H335
• 예방조치 성명서: P261 - P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves