M5571

Miltefosine

≥98% (perchloric acid titration)

• 동의어(들): Choline hexadecyl phosphate, HePC, Hexadecyl phosphocholine
• 실험식(Hill 표기법): C₂₁H₄₆NO₄P
• CAS Number: 58066-85-6
• Molecular Weight: 407.57
• MDL number: MFCD00133396
• UNSPSC 코드: 51191904
• PubChem Substance ID: 329818017
• NACRES: NA.85

속성

• 생물학적 소스: synthetic (organic)
• Quality Level: 200
• 설명: zwitterionic
• 분석: ≥98% (perchloric acid titration)
• 양식: powder
• solubility: H₂O: 10 mg/mL, clear, colorless
• 작용기: phospholipid
• 지질 유형: phospholipids
• 저장 온도: room temp
• SMILES string: [O-]P(OCC[N+](C)(C)C)(OCCCCCCCCCCCCCCCC)=O
• InChI: 1S/C21H46NO4P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-25-27(23,24)26-21-19-22(2,3)4/h5-21H2,1-4H3
• InChI key: PQLXHQMOHUQAKB-UHFFFAOYSA-N

설명

애플리케이션

• Easy one-pot synthesis of multifunctionalized indole-pyrrole hybrids as a new class of antileishmanial agents.: This study underlines the necessity for innovative treatments amidst growing resistance to established drugs such as miltefosine which is used as a positive control reference, potentially setting a new direction for antileishmanial drug development (Ciccone et al., 2024).

생화학적/생리학적 작용

Inhibitor of protein kinase C and of phosphatidylcholine synthesis. Used for the treatment of visceral and cutaneous leishmaniasis. Active against metronidazole-resistant and -susceptible strains of Trichomonas vaginalis

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301
• 예방조치 성명서: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves