N8534

Nilutamide

solid

• 동의어(들): 5,5-Dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-2,4-imidazolidinedione, Anandron, RU-23908
• 실험식(Hill 표기법): C₁₂H₁₀F₃N₃O₄
• CAS Number: 63612-50-0
• Molecular Weight: 317.22
• MDL number: MFCD00864670
• UNSPSC 코드: 51111800
• PubChem Substance ID: 24278596
• NACRES: NA.77

속성

• 양식: solid
• Quality Level: 200
• 주관자: Sanofi Aventis
• SMILES string: CC1(C)NC(=O)N(c2ccc(c(c2)C(F)(F)F)[N+]([O-])=O)C1=O
• InChI: 1S/C12H10F3N3O4/c1-11(2)9(19)17(10(20)16-11)6-3-4-8(18(21)22)7(5-6)12(13,14)15/h3-5H,1-2H3,(H,16,20)
• InChI key: XWXYUMMDTVBTOU-UHFFFAOYSA-N
• 유전자 정보: human ... AR(367)

설명

애플리케이션

Nilutamide has been used:

• as a nuclear androgen receptor (nAR) inhibitor to study its effects on oocyte maturation in zebrafish
• to determine its effects on bioluminescent Saccharomyces cerevisiae bioreporters in BLYAS assay
• as a substrate in hydrogenation reaction

생화학적/생리학적 작용

Nilutamide is a nuclear androgen receptor inhibitor. It is a nonsteroidal antiandrogen that competitively inhibits the binding of dihydrotestosterone to the androgen receptor. Nilutamide shows a therapeutic effect against prostate cancer.

특징 및 장점

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H301,H360
• 예방조치 성명서: P201 - P301 + P310 + P330
• Hazard Classifications: Acute Tox. 3 Oral - Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges