S0383

Sulfameter

• 동의어(들): 5-Methoxysulfadiazine, N¹-(5-Methoxypyrimidin-2-yl)sulfanilamide, Sulfamethoxydiazine
• 실험식(Hill 표기법): C₁₁H₁₂N₄O₃S
• CAS Number: 651-06-9
• Molecular Weight: 280.30
• Beilstein: 621130
• EC Number: 211-480-8
• MDL number: MFCD00006067
• UNSPSC 코드: 51283913
• PubChem Substance ID: 24899422
• NACRES: NA.85

속성

• 양식: powder
• Quality Level: 200
• 저장 조건: (Keep container tightly closed in a dry and well-ventilated place. Light sensitive.)
• 색상: white to faint yellow
• 항생제 활성 스펙트럼: Gram-negative bacteria; Gram-positive bacteria; mycobacteria; parasites
• 동작 모드: enzyme | inhibits
• 저장 온도: 2-8°C
• SMILES string: COc1cnc(NS(=O)(=O)c2ccc(N)cc2)nc1
• InChI: 1S/C11H12N4O3S/c1-18-9-6-13-11(14-7-9)15-19(16,17)10-4-2-8(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15)
• InChI key: GPTONYMQFTZPKC-UHFFFAOYSA-N

설명

일반 설명

Chemical structure: sulfonamide

애플리케이션

Sulfameter is a sulfonamide antibiotic used as a leprostatic agent and to treat urinary tract infections. It has been investigated as a potential therapy for chloroquine-resistant malaria during pregnancy.

생화학적/생리학적 작용

Sulfameter is a sulfonamide antibiotic. Sulfonamides block the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfonamides are competitive inhibitors of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. Sulfameter is a dihydrofolate reductase (DHFR) inhibitor. Sulfonamides are active against Gram positive bacteria and Gram negative bacteria. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

기타 정보

Keep container tightly closed in a dry and well-ventilated place. Light sensitive.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves