S1825

S32826 disodium salt hydrate

≥98% (HPLC)

• 동의어(들): [4-(Tetradecanoylamino)benzyl]phosphonic acid disodium salt hydrate
• 실험식(Hill 표기법): C₂₁H₃₄NNa₂O₄P · xH₂O
• CAS Number: 1096770-84-1
• Molecular Weight: 441.45 (anhydrous basis)
• MDL number: MFCD12912442
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329824492
• NACRES: NA.25

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• 색상: white
• solubility: H₂O: ≥10 mg/mL
• 저장 온도: −20°C
• SMILES string: [Na+].[Na+].CCCCCCCCCCCCCC(=O)Nc1ccc(CP([O-])([O-])=O)cc1
• InChI: 1S/C21H36NO4P.2Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-21(23)22-20-16-14-19(15-17-20)18-27(24,25)26;;/h14-17H,2-13,18H2,1H3,(H,22,23)(H2,24,25,26);;/q;2*+1/p-2
• InChI key: DGRFALMFDGBLCP-UHFFFAOYSA-L

설명

애플리케이션

S32826, a potent inhibitor of autotaxin (ATX), may be used to identify and characterize the lyso-phospholipase D (lysoPLD, ATX) involved in bioactive lyso-phosphatidic acid (LPA) formation. S32826 may be used to help determine the role of ATX in malignant cell processes such as tumorigenesis, invasion, and metastases; cardia bifida and atherosclerosis.

생화학적/생리학적 작용

S32826 is a potent inhibitor of autotaxin.

S32826 is a potent inhibitor of autotaxin. Autotaxin is a newly discovered lyso-phospholipase D (lysoPLD). Autotaxin and lyso-phosphatidic acid (LPA) have been associated with early cancer progression and motility of cancer cells as well as with metastasis. Because of localization (adipose tissue), the enzyme might play an important role in diabetes and obesity. Autotaxin might be the only source of LPA. S32826 is the strongest inhibitor of autotaxin reported. The compound shows activity in cellular or ex vivo models.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)