S4568

SCH 58261

≥98% (HPLC), solid

• 동의어(들): 7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine
• 실험식(Hill 표기법): C₁₈H₁₅N₇O
• CAS Number: 160098-96-4
• Molecular Weight: 345.36
• MDL number: MFCD00933778
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329824547
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 색상: off-white
• solubility: DMSO: soluble >10 mg/mL; H₂O: insoluble
• SMILES string: Nc1nc2n(CCc3ccccc3)ncc2c4nc(nn14)-c5ccco5
• InChI: 1S/C18H15N7O/c19-18-22-16-13(11-20-24(16)9-8-12-5-2-1-3-6-12)17-21-15(23-25(17)18)14-7-4-10-26-14/h1-7,10-11H,8-9H2,(H2,19,22)
• InChI key: UTLPKQYUXOEJIL-UHFFFAOYSA-N

설명

애플리케이션

SCH 58261 was used to block A2α adenosine receptor to study the signaling by prostatic acid phosphatase in neurons.⁴

생화학적/생리학적 작용

A_2A adenosine receptor antagonist.

SCH 58261 reduces the levels of TNF-α, Fas-L, Bax expression and activation of JNK-MAPK pathway. It has neuroprotective effects as it reduces demyelination of the neurons. SCH 58261 increases the concentration of secretion of dopamine and elicits locomotor sensitization, an attractive option in the possible treatment of Parkinson′s disease.

특징 및 장점

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)