S5321

S15535

≥98% (HPLC), solid

• 동의어(들): 1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-4-(2,3-dihydro-1h-inden-2-yl)-piperazine
• 실험식(Hill 표기법): C₂₁H₂₄N₂O₂
• CAS Number: 146998-34-7
• Molecular Weight: 336.43
• MDL number: MFCD00911672
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329824452
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 색상: white
• solubility: DMSO: ~6 mg/mL; H₂O: insoluble
• 저장 온도: 2-8°C
• SMILES string: C1COc2c(O1)cccc2N3CCN(CC3)C4Cc5ccccc5C4
• InChI: 1S/C21H24N2O2/c1-2-5-17-15-18(14-16(17)4-1)22-8-10-23(11-9-22)19-6-3-7-20-21(19)25-13-12-24-20/h1-7,18H,8-15H2
• InChI key: QJPPEMXOOWNICQ-UHFFFAOYSA-N

설명

애플리케이션

S15535 has been used as a serotonin 1A receptor (5-HT1A) agonist in zebrafish.

S15535 may be used in histamine 5-HT_1A-medaited cell signaling studies.

생화학적/생리학적 작용

Potent, orally active, partial 5-HT_1A receptor agonist

S15535, a benzodioxane, is a selective but partial agonist of histamine serotonin 1A (5-HT_1A) receptor. It activates presynaptic 5-HT_1A receptors and suppresses the release of hippocampal 5-HT. It acts as an anxiolytic agent and modulates the cholinergic and cognitive function in rodents.

안전성 정보

• 픽토그램: GHS09
• 신호어: Warning
• 유해 및 위험 성명서: H410
• 예방조치 성명서: P273 - P391 - P501
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves