S7936

SB 205384

solid

• 동의어(들): 4-Amino-7-hydroxy-2-methyl-5,6,7,8-tetrahydrobenzo[b]thieno[2,3-b]pyridine-3-carboxylic acid but-2-ynyl ester
• 실험식(Hill 표기법): C₁₇H₁₈N₂O₃S
• CAS Number: 160296-13-9
• Molecular Weight: 330.40
• MDL number: MFCD00918851
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278711
• NACRES: NA.77

속성

• 양식: solid
• Quality Level: 100
• 색상: off-white
• solubility: DMSO: 18 mg/mL; H₂O: insoluble
• SMILES string: CC#CCOC(=O)c1c(C)nc2sc3CC(O)CCc3c2c1N
• InChI: 1S/C17H18N2O3S/c1-3-4-7-22-17(21)13-9(2)19-16-14(15(13)18)11-6-5-10(20)8-12(11)23-16/h10,20H,5-8H2,1-2H3,(H2,18,19)
• InChI key: JDTZAGLGBRRCJT-UHFFFAOYSA-N

설명

애플리케이션

SB 205384 was used to study GABA-gated currents in rat locus coeruleus neurons.⁶

생화학적/생리학적 작용

GABA_A receptor modulator selective for the α₃β₂γ₂ subunit combination.

SB 205384 is a selective and positive allosteric modulator of non-benzodiazepine site of the GABA_A receptor.³ It affects the extrasynaptic GABA_A receptors in rat cortical neurons⁴ and enhances the GABAergic transmission onto pro-opiomelanocortin neurons in mice.⁵

법적 정보

Manufactured and sold under license from GlaxoSmithKline Pharmaceuticals

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)