S7942

Sirtinol

≥95% (HPLC)

• 동의어(들): 2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide
• 실험식(Hill 표기법): C₂₆H₂₂N₂O₂
• CAS Number: 410536-97-9
• Molecular Weight: 394.47
• MDL number: MFCD00810186
• UNSPSC 코드: 12352203
• PubChem Substance ID: 24899771
• NACRES: NA.77

속성

• Quality Level: 200
• 분석: ≥95% (HPLC)
• 양식: solid
• solubility: DMSO: soluble
• 저장 온도: −20°C
• SMILES string: CC(NC(=O)c1ccccc1\N=C\c2c(O)ccc3ccccc23)c4ccccc4
• InChI: 1S/C26H22N2O2/c1-18(19-9-3-2-4-10-19)28-26(30)22-13-7-8-14-24(22)27-17-23-21-12-6-5-11-20(21)15-16-25(23)29/h2-18,29H,1H3,(H,28,30)/b27-17+
• InChI key: UXJFDYIHRJGPFS-WPWMEQJKSA-N
• 유전자 정보: human ... SIRT1(23411), SIRT2(22933)

설명

애플리케이션

HUVEC were treated with sirtinol to study the effect on induction of transcription factor Krüppel-like factor 2.⁴ Sirtinol was used to treat human embryonic kidney cells to study the effect on the expression on Werner syndrome protein.⁵

생화학적/생리학적 작용

Sirtinol inhibits yeast Sir2p transcriptional silencing activity in vivo, yeast Sir2p and human SIRT2 deacetylase activity in vitro. It inhibits the physiological regulators of platelet aggregation such as thrombin and collagen, attenuates intracellular Ca²⁺ release and formation thromboxane B2. It may increase levels of cAMP by inhibition of cAMP phosphodiesterase and inhibit the aggregation of platelets.² Sirtinol reduces inflammatory responses of human dermal microvascular endothelial cells to TNF-α and IL-1β.³

Sirtinol inhibits yeast Sir2p transcriptional silencing activity in vivo, yeast Sir2p, and human SIRT2 deacetylase activity in vitro.

특징 및 장점

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안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)