S8197

SMER28

>99% (HPLC), solid

• 동의어(들): 6-Bromo-N-2-propenyl-4-quinazolinamine
• 실험식(Hill 표기법): C₁₁H₁₀BrN₃
• CAS Number: 307538-42-7
• Molecular Weight: 264.12
• MDL number: MFCD02166825
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329824598
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: >99% (HPLC)
• 양식: solid
• solubility: DMSO: >20 mg/mL; H₂O: insoluble
• 저장 온도: 2-8°C
• SMILES string: Brc1ccc2ncnc(NCC=C)c2c1
• InChI: 1S/C11H10BrN3/c1-2-5-13-11-9-6-8(12)3-4-10(9)14-7-15-11/h2-4,6-7H,1,5H2,(H,13,14,15)
• InChI key: BCPOLXUSCUFDGE-UHFFFAOYSA-N

설명

애플리케이션

SMER28 may be used in mTOR-mediated signaling studies.

생화학적/생리학적 작용

SMER28 is a small molecule modulator of mammalian autophagy.

SMER28 is a small molecule modulator of mammalian autophagy; enhances A53T alpha-synuclein clearance in PC-12 cells independent of rapamycin treatment; appears to act independent of the mTOR pathway, but combined treatment with saturating rapamycin concentration enhances the effect of either compound alone on A53T alpha-synuclein clearance; autophagy inducers may prove useful in the treatment of neurodegenerative and infectious diseases and cancer.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves