SAB4700284

Monoclonal Anti-CD15 antibody produced in mouse

clone MEM-158, purified immunoglobulin, buffered aqueous solution

• 동의어(들): Anti-FUT4, Anti-Lewis x Blood Group antigen
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: MEM-158, monoclonal
• 양식: buffered aqueous solution
• 종 반응성: human
• 농도: 1 mg/mL
• 기술: flow cytometry: suitable
• 동형: IgM
• NCBI 수납 번호: NM_002033.3
• UniProt 수납 번호: P22083
• 배송 상태: wet ice
• 저장 온도: 2-8°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... FUT4(2526)

설명

일반 설명

Cluster of differentiation 15 (CD15), also known as fucosyltransferase 4 (FUT4)/ Lewis x blood group antigen, is encoded by the gene mapped to long arm of human chromosome 11q21. It is ubiquitously expressed in various tissues such as gastrointestinal tract, brain and leukocytes.

The antibody MEM-158 reacts with CD15, a cell membrane molecule 3-fucosyl-N-acetyllactosamine (3-FAL) strongly expressed on granulocytes, monocytes, macrophages, mast cells; it is also present on Langerhans cells and some myeloid precursors cells.

면역원

Human granulocytes

애플리케이션

The reagent is designed for Flow Cytometry analysis using 10 μL reagent / 100 μL of sample.

생화학적/생리학적 작용

Cluster of differentiation 15 (CD15)/fucosyltransferase 4 catalyzes the synthesis of Le^x on the surface of the proliferating cells, in organ buds progressing in mesenchyma, during human embryogenesis. Overexpression of the gene has been associated with development of various type of cancers such as colon cancer, pancreatic cancer, gastric cancer and lung adenocarcinoma. siRNAs of FUT1/4 can be used as a potent therapeutic agent in human LeY-expressing cancers.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable