SCP0148

Furin Inhibitor II Peptide

≥95% (HPLC), lyophilized powder

• 동의어(들): Hexa-D-arginine amide
• 실험식(Hill 표기법): C₃₆H₇₅N₂₅O₆
• Molecular Weight: 954.14
• UNSPSC 코드: 12352202
• NACRES: NA.32

속성

• Product Name: Furin Inhibitor II,
• 분석: ≥95% (HPLC)
• 양식: lyophilized
• 구성: Peptide Content, ≥48%
• 저장 조건: protect from light
• 기술: protein extraction: suitable
• 저장 온도: −20°C

설명

Amino Acid Sequence

Mpa-Mpa-Mpa-Mpa-Mpa-Mpa

일반 설명

Furin is a calcium-dependent serine endoproteinase and belongs to the subtilisin-like proprotein/prohormone convertase (PC) family. It is distributed ubiquitously and has a rhythmic movement between the trans-Golgi network, cell surface and the endosomes.

애플리케이션

Furin Inhibitor II has been used as a furin inhibitor:

• to study its effects on transforming growth factor β1 (TGF-β1) induced glial cell line-derived neurotrophic factor (GDNF) production in non-tumorigenic immortalized human granulosa cell line (SVOG).
• to study its effect on cleavage of (Pro) renin receptor (PRR) induced by bovine serum albumin (BSA) in human kidney 2 (HK-2) cells.
• in furin cleavage assay.

생화학적/생리학적 작용

Furin plays a role in processing several pro-proteins such as, bone morphogenetic protein 4 (BMP-4), insulin receptor and Notch1 receptor. It also processes human immune deficiency virus 1 (HIV-1) glycoprotein gp160, several metalloproteases and pro-β-nerve growth (pro-β-NGF) factor. Furin is also involved in cleaving transforming growth factor β1 (TGF-β1).

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable