SMB00387

Prothionamide

≥99% (HPLC)

• 동의어(들): Prothionamide, 2-propyl-4-pyridinecarbothioamide, 2-propylisonicotinylthioamide, 2-propylthioisonicotinamide, 2-Propyl-4-pyridinecarbothioamide, 2-Propylisonicotinylthioamide
• 실험식(Hill 표기법): C₉H₁₂N₂S
• CAS Number: 14222-60-7
• Molecular Weight: 180.27
• MDL number: MFCD00464119
• UNSPSC 코드: 51102829
• PubChem Substance ID: 329824982
• NACRES: NA.85

속성

• Quality Level: 200
• 분석: ≥99% (HPLC)
• 양식: powder
• 색상: yellow
• 항생제 활성 스펙트럼: mycobacteria
• 동작 모드: enzyme | interferes
• 저장 온도: −20°C
• SMILES string: NC(C1=CC(CCC)=NC=C1)=S
• InChI: 1S/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12)
• InChI key: VRDIULHPQTYCLN-UHFFFAOYSA-N

설명

일반 설명

Chemical structure: pyridine

Prothionamide is an analogue of ethionamide, and is better tolerated and less toxic than ethionamide. It contains a propyl group instead of an ethyl group at the α position.

생화학적/생리학적 작용

Prothionamide is the second line of drug used in leprosy and in tuberculosis. It is highly effective against Mycobacterium tuberculosis. In patients with multidrug-resistant tuberculosis (MDR-TB), prothionamide causes the development of hepatitis. In rare cases, it causes drug reaction with eosinophilia and systemic symptoms (DRESS) in patients with MDR-TB. DRESS is characterized by fever, hematologic abnormalities, skin eruption, and internal organ disruption.

저장 및 안정성

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Non Combustible liquids.

기타 정보

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable