SML0124

Rasagiline mesylate

≥98% (HPLC)

• 동의어(들): (1R)-2,3-Dihydro-N-2-propynl-1H-inden-1-amine methanesulfonate, N-Propargyl-1(R)-aminoindan methanesulfonate, TVP-1012
• 실험식(Hill 표기법): C₁₂H₁₃N · CH₄O₃S
• CAS Number: 161735-79-1
• Molecular Weight: 267.34
• MDL number: MFCD08460604
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825174
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 광학 활성: [α]/D +15 to +28°, c = 0.6 mg/mL in H₂O
• 저장 조건: desiccated
• 색상: white to tan
• solubility: H₂O: ≥20 mg/mL
• 저장 온도: 2-8°C
• SMILES string: CS(O)(=O)=O.C#CCN[C@@H]1CCc2ccccc12
• InChI: 1S/C12H13N.CH4O3S/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12;1-5(2,3)4/h1,3-6,12-13H,7-9H2;1H3,(H,2,3,4)/t12-;/m1./s1
• InChI key: JDBJJCWRXSVHOQ-UTONKHPSSA-N
• 유전자 정보: human ... MAOB(4129)

설명

애플리케이션

Rasagiline mesylate has been used:

• to test its neuroprotective effects in retinitis pigmentosa (RP) by apoptosis regulator, Bax/Bcl-2 modulation
• as monoamine oxidase-B inhibitor in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced mouse model
• as an anti-parkinsonian agent to test its rescue functionality in 6-hydroxydopamine-lesioned zebrafish larvae towards bradykinetic and dyskinetic-like behavior

Rasagiline mesylate may be used in MAO type B-mediated cell signaling studies.

생화학적/생리학적 작용

Anti-Parkinson drug; MAO B Inhibitor; anti-apoptotic; neuroprotectant

Rasagiline mesylate is an effective therapeutic option in early stages of Parkinson′s disease. It improves the motor fluctuations in levodopa-treated patients and may be a useful adjunct to such patients. It has neuroprotective effects and increases the survival of dopaminergic neurons.

Rasagiline mesylate is an irreversible inhibitor of monoamine oxidase selective for MAO type B over type A by a factor of fourteen. It has anti-apoptotic and neuroprotectant activity and has been used as a treatment for Parkinson′s disease.

특징 및 장점

This compound is featured on the Dopamine and Norepinephrine Metabolism and Histamine Synthesis and Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable