SML0147

Drospirenone

≥98% (HPLC)

• 동의어(들): 6β,7β:15β,16β -Dimethylene-3-oxo-17α-pregn-4-ene-21,17-carbolactone, Dihydrospirorenone
• 실험식(Hill 표기법): C₂₄H₃₀O₃
• CAS Number: 67392-87-4
• Molecular Weight: 366.49
• EC Number: 266-679-2
• MDL number: MFCD00867350
• UNSPSC 코드: 51111800
• PubChem Substance ID: 329825195
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 광학 활성: [α]/D -180 to -195°, c = 1 in methanol
• 저장 조건: desiccated
• 색상: white to tan
• solubility: DMSO: ≥15
• 주관자: Bayer
• 저장 온도: 2-8°C
• SMILES string: C[C@]12CCC(=O)C=C1[C@@H]3C[C@@H]3[C@@H]4[C@@H]2CC[C@@]5(C)[C@H]4[C@@H]6C[C@@H]6[C@@]57CCC(=O)O7
• InChI: 1S/C24H30O3/c1-22-6-3-12(25)9-17(22)13-10-14(13)20-16(22)4-7-23(2)21(20)15-11-18(15)24(23)8-5-19(26)27-24/h9,13-16,18,20-21H,3-8,10-11H2,1-2H3/t13-,14+,15-,16+,18+,20-,21+,22-,23+,24+/m1/s1
• InChI key: METQSPRSQINEEU-HXCATZOESA-N
• 유전자 정보: human ... NR3C2(4306), PGR(5241)

설명

애플리케이션

Drospirenone has been used as a progestogen agent in pond snail and fish.

Drospirenone was tested for genotoxicity in rat and human hepatocytes.

생화학적/생리학적 작용

Drospirenone is a fourth-generation progestin that has antimineralocorticoid, and antiandrogenic activity in addition to potent progestogenic activity. In two recent studies drospirenone appeared to double the risk of venous thromboembolism compared to levonorgestrel, although other studies found little added risk.

Fourth-generation progestin; contraceptive

특징 및 장점

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H360
• 예방조치 성명서: P201 - P308 + P313
• Hazard Classifications: Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable