SML0238

WEB2086

≥98% (HPLC)

• 동의어(들): 3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-(4-morpholinyl)-1-propanone, Apafant, WEB 2086BS
• 실험식(Hill 표기법): C₂₂H₂₂ClN₅O₂S
• CAS Number: 105219-56-5
• Molecular Weight: 455.96
• MDL number: MFCD00865271
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825250
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• 색상: white to beige
• solubility: DMSO: 10 mg/mL (clear solution)
• 저장 온도: 2-8°C
• SMILES string: Cc1nnc2CN=C(c3ccccc3Cl)c4cc(CCC(=O)N5CCOCC5)sc4-n12
• InChI: 1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3
• InChI key: JGPJQFOROWSRRS-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

WEB 2086 inhibits PAF mediated chemotaxis and leukotriene C4 production in eosinophils. It prevents surge in airway resistance and cardiovascular side effects mediated by PAF inhalation.

WEB2086 is a very potent, selective platelet-activating factor (PAF) antagonist (IC₅₀ = 16 nM). WEB2086 inhibits the proliferation of tumor cells and slows tumor growth in xenograft tumor models, and has been shown to inhibit angiogenesis.

WEB2086 is a very potent, selective platelet-activating factor (PAF) antagonist.

특징 및 장점

This compound is featured on the PAF Receptor page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable