P6500

Pentylenetetrazole

≥99% (GC), powder, CNS stimulant

• 동의어(들): α,β-Cyclopentamethylenetetrazole, 1,5-Pentamethylenetetrazole, 6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine, Metrazole
• 실험식(Hill 표기법): C₆H₁₀N₄
• CAS Number: 54-95-5
• Molecular Weight: 138.17
• EC Number: 200-219-3
• MDL number: MFCD00005939
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278643
• NACRES: NA.77

속성

• Product Name: Pentylenetetrazole,
• 양식: powder
• Quality Level: 100
• bp: 194 °C/12 mmHg (lit.)
• mp: 59-61 °C (lit.)
• 저장 온도: −20°C
• SMILES string: C1CCc2nnnn2CC1
• InChI: 1S/C6H10N4/c1-2-4-6-7-8-9-10(6)5-3-1/h1-5H2
• InChI key: CWRVKFFCRWGWCS-UHFFFAOYSA-N

설명

일반 설명

Pentylenetetrazole (PTZ) is a tetrazole derivative and inhibitor of the γ aminobutyric acid (GABAA) and its receptor complex. PTZ is a convulsing agent used for inducing seizures. It can traverse the blood-brain barrier.

애플리케이션

Pentylenetetrazole has been used to induce seizures in zebra fish larvae, mice, and male wistar rats.

생화학적/생리학적 작용

Pentylenetetrazole is a non-specific central nervous system (CNS) stimulant and convulsant. PTZ induces oxidative stress and increases cortical malondialdehyde content and affects hippocampus, resulting in seizures.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301,H315,H319,H335
• 예방조치 성명서: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges