SML0480

Terreic Acid

from Aspergillus terreus, ≥98% (HPLC)

• 실험식(Hill 표기법): C₇H₆O₄
• CAS Number: 121-40-4
• Molecular Weight: 154.12
• UNSPSC 코드: 12352106
• NACRES: NA.77

속성

• 생물학적 소스: Aspergillus terreus
• Quality Level: 200
• 분석: ≥98% (HPLC)
• 양식: solid
• solubility: DMSO: 10 mg/mL; H₂O: 2 mg/mL
• 저장 온도: −20°C
• InChI: 1S/C7H6O4/c1-2-3(8)5(10)7-6(11-7)4(2)9/h6-8H,1H3/t6-,7+/m1/s1
• InChI key: ATFNSNUJZOYXFC-RQJHMYQMSA-N

설명

애플리케이션

Terreic Acid has been used to study its effect on alcohol intake and blood alcohol levels (BALs) in High Drinking in the Dark (HDID-1) mice. It has also been used as a supplement for culturing yeast progenitor cells to study its effect on yeast replicative lifespan.

생화학적/생리학적 작용

Terreic acid (TA) is a covalent inhibitor of the bacterial cell wall biosynthetic enzyme MurA.

Terreic acid (TA) is a covalent inhibitor of the bacterial cell wall biosynthetic enzyme MurA. The survival of most bacteria depends on the functionality of this cytosolic enzyme. The inactivation of MurA requires the presence of UDP-N-acetylglucosamine 1-Carboxyvinyl transferase, which catalyzes the first step in the biosynthesis of the bacterial cell wall. TA is more potent than the known MurA inhibitor Fosphomycin. TA was also found to severely inhibit the transcription of TNFα and IL-2. TA inhibits protein synthesis by blocking the formation of leucyl-tRNA in sensitive bacteria and inhibits the catalytic effect of Bruton′s tyrosine kinase (Btk), an important factor in B-cell and mast cell activation, by inducing conformational changes that prevent Protein Kinase C (PKC) from interacting with the Btk domain. Moreover, recent studies have demonstrated that TA exhibits a very high level of radical scavenging activity.

특징 및 장점

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제조 메모

Store the product sealed at -20 °C. Under these conditions the product is stable for at least 2 years. Solution of the product in water is not stable and should be prepared immediately before use. Solution of the product in DMSO is stable for at least 2 months at 4 °C.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable