SML0499

NCTT-956

≥97% (NMR)

• 동의어(들): N-[(8-Hydroxy-5-nitro-7-quinolinyl)-2-thienylmethyl]-propanamide
• 실험식(Hill 표기법): C₁₇H₁₅N₃O₄S
• CAS Number: 438575-88-3
• Molecular Weight: 357.38
• MDL number: MFCD02228855
• UNSPSC 코드: 51111800
• PubChem Substance ID: 329825448
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥97% (NMR)
• 양식: powder
• 색상: light orange to dark orange
• solubility: DMSO: 5 mg/mL (clear solution)
• 저장 온도: 2-8°C
• SMILES string: CCC(=O)NC(c1cccs1)c2cc([N+]([O-])=O)c3cccnc3c2O
• InChI: 1S/C17H15N3O4S/c1-2-14(21)19-15(13-6-4-8-25-13)11-9-12(20(23)24)10-5-3-7-18-16(10)17(11)22/h3-9,15,22H,2H2,1H3,(H,19,21)
• InChI key: DEXNORPUTBBNSC-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

NCTT-956 is a potent, specific 12-LO inhibitor.

NCTT-956 is a very potent, specific inhibitor of 12-lipoxygenase (12-LO) activity, with an IC₅₀ of 800 nM, no activity against 5-LO and greater than 25-fold selectivity over 15-LO. Specific inhibition of 12-LO by NCTT-956 in platelets blocks PKC activation, aggregation, granule secretion and αIIbB3 activation.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302,H319
• 예방조치 성명서: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable