X2254

XE-991

≥98% (HPLC), powder, KCNQ channel blocker

• 동의어(들): 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone
• 실험식(Hill 표기법): C₂₆H₂₀N₂O
• CAS Number: 122955-42-4
• Molecular Weight: 376.45
• MDL number: MFCD05662331
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329830775
• NACRES: NA.77

속성

• Product Name: XE-991, ≥98% (HPLC)
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 색상: white to beige
• solubility: DMSO: >20 mg/mL
• 주관자: Merck & Co., Inc., Kenilworth, NJ, U.S.
• 저장 온도: 2-8°C
• SMILES string: O=C1c2ccccc2C(Cc3ccncc3)(Cc4ccncc4)c5ccccc15
• InChI: 1S/C26H20N2O/c29-25-21-5-1-3-7-23(21)26(17-19-9-13-27-14-10-19,18-20-11-15-28-16-12-20)24-8-4-2-6-22(24)25/h1-16H,17-18H2
• InChI key: KHJFBUUFMUBONL-UHFFFAOYSA-N

설명

애플리케이션

XE-991 has been used as a KCNQ (Kv7.2/7.3) inhibitor to examine whether M-current inhibition affects oxytocin receptor (TGOT) mediated depolarization. It has also been used as an KCNQ inhibitor to study the ionic mechanism responsible for the overshoot/undershoot in membrane potential in mouse cholinergic interneurons (ChIs) in the presence of tetrodotoxin (TTX).

생화학적/생리학적 작용

XE-991 is a KCNQ channel blocker.

XE-991 is a KCNQ channel blocker; which is more potent than linopiridine (Cat. No. L-134).

특징 및 장점

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable