추천 제품
Quality Level
분석
≥97% (NMR)
양식
powder
색상
white to beige
solubility
DMSO: 20 mg/mL, clear
저장 온도
−20°C
SMILES string
Clc1cc2c(cc1)OC(=C(C2C(C(=O)OCC)C#N)C(=O)OCC)N
InChI
1S/C17H17ClN2O5/c1-3-23-16(21)11(8-19)13-10-7-9(18)5-6-12(10)25-15(20)14(13)17(22)24-4-2/h5-7,11,13H,3-4,20H2,1-2H3
InChI key
DXVKFBGVVRSOLI-UHFFFAOYSA-N
관련 카테고리
애플리케이션
SC79 has been used in western blot analysis as a positive control to measure the extent of phosphorylation of Akt and also to activate Akt that has been suppressed by nitidine chloride, a natural bioactive alkaloid.
생화학적/생리학적 작용
SC79 is an AKT activator.
SC79 is an AKT activator. SC79 binds to the plecktrin homology (PH) domain of Akt that mimics the binding of PtdIns(3,4,5)P3 to induce a conformational change in Akt that enhances phosphorylation and activation. SC79 induces cytosolic Akt signaling in cell based assays, and prevents neuronal death in a mouse model of stroke.
특징 및 장점
This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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