SML0897

ALX 5407 hydrochloride

≥98% (HPLC)

• 동의어(들): ALX-5407 hydrochloride, N-[3-(4′-Fluorophenyl)-3-(4′-phenylphenoxy)propyl]sarcosine hydrochloride, NFPS hydrochloride
• 실험식(Hill 표기법): C₂₄H₂₄NO₃F·HCl
• CAS Number: 200006-08-2
• Molecular Weight: 429.91
• MDL number: MFCD09971056
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825613
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• 색상: white to beige
• solubility: DMSO: 5 mg/mL, clear (warmed)
• 저장 온도: 2-8°C
• SMILES string: Cl.CN(CC[C@@H](Oc1ccc(cc1)-c2ccccc2)c3ccc(F)cc3)CC(O)=O
• InChI: 1S/C24H24FNO3.ClH/c1-26(17-24(27)28)16-15-23(20-7-11-21(25)12-8-20)29-22-13-9-19(10-14-22)18-5-3-2-4-6-18;/h2-14,23H,15-17H2,1H3,(H,27,28);1H/t23-;/m1./s1
• InChI key: RPDGSZCYSJWQEE-GNAFDRTKSA-N

설명

애플리케이션

ALX 5407 hydrochloride has been used as a glycine transporter (GlyT1) inhibitor to test its effect on inhibitory postsynaptic current and N-methyl-D-aspartate receptor (NMDA)-mediated excitatory postsynaptic currents (EPSCs). It has also been used as a GlyT1 inhibitor to treat developmentally diminished NMDA receptor (Grin1D481N) mice to test its effect on the glycine site function.

생화학적/생리학적 작용

ALX 5407 is a selective, irreversible GlyT-1 glycine transporter inhibitor.

ALX-5407 hydrochloride (NFPS hydrochloride) is a selective irreversible inhibitor of the glycine transporter GlyT1 with IC₅₀ values of 3 nM for GlyT1 compared to 100 μM for GlyT2. ALX-5407 hydrochloride showed no activity at the inhibitory glycine receptor or glycine site of the NMDA receptor (IC₅₀ > 100 mM).

특징 및 장점

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안전성 정보

• 픽토그램: GHS07,GHS09
• 신호어: Warning
• 유해 및 위험 성명서: H302,H410
• 예방조치 성명서: P264 - P270 - P273 - P301 + P312 - P391 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable