SML1183

BMH-21

≥98% (HPLC)

• 동의어(들): N-[2-(Dimethylamino)ethyl]-12-oxo-2H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
• 실험식(Hill 표기법): C₂₁H₂₀N₄O₂
• CAS Number: 896705-16-1
• Molecular Weight: 360.41
• MDL number: MFCD27225377
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825705
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: faint yellow to dark orange
• solubility: DMSO: 1 mg/mL, clear (warmed)
• 저장 온도: 2-8°C
• SMILES string: O=C(N(C=CC=C1C(NCCN(C)C)=O)C1=N2)C(C2=C3)=CC4=C3C=CC=C4
• InChI: 1S/C21H20N4O2/c1-24(2)11-9-22-20(26)16-8-5-10-25-19(16)23-18-13-15-7-4-3-6-14(15)12-17(18)21(25)27/h3-8,10,12-13H,9,11H2,1-2H3,(H,22,26)
• InChI key: BXYDVWIAGDJBEC-UHFFFAOYSA-N

설명

일반 설명

BMH-21 is a planar heterocyclic small molecule DNA intercalator.

애플리케이션

BMH-21 has been used in cell culture.

생화학적/생리학적 작용

BMH-21 has the ability to bind ribosomal DNA and prevent RNA polymerase I (Pol I) transcription and results in the disintegration of the nucleolus. It does not impair DNA damage detection. BMH-21 is considered as an important activator of the p53 pathway.

BMH-21 is a potent inhibitor of RNA Pol I.

BMH-21 is a potent inhibitor of RNA Pol I. BMH-21 binds strongly to GC-rich DNA sequences, ultimately inhibiting RNA Pol I, blocking transcription and disrupting the nucleolar structure. BMH-1 causes dissociation of the RPA194 catalytic subunit from Pol I, and disassembly of Pol I:DNA complexes. The compound BMH-21 inhibits proliferation of a broad range of tumor cell lines.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable