SML1241

Pyr6

≥98% (HPLC)

• 동의어(들): N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide
• 실험식(Hill 표기법): C₁₇H₉F₇N₄O
• CAS Number: 245747-08-4
• Molecular Weight: 418.27
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825738
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 20 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: O=C(C1=CC=NC=C1F)NC2=CC=C(N3C(C(F)(F)F)=CC(C(F)(F)F)=N3)C=C2
• InChI: 1S/C17H9F7N4O/c18-12-8-25-6-5-11(12)15(29)26-9-1-3-10(4-2-9)28-14(17(22,23)24)7-13(27-28)16(19,20)21/h1-8H,(H,26,29)
• InChI key: XZIQSOZOLJJMFN-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

Pyr6 is a selective inhibitor of calcium release from the endoplasmic reticulum via STIM1/Orai1 mediated, store operated calcium entry (SOCE).

Pyr6 is a selective inhibitor of calcium release from the endoplasmic reticulum via STIM1/Orai1 mediated, store operated calcium entry (SOCE). Pyr6 blocks SOCE in thapsigargin treated, calcium depleted BRL-2H3 cells (IC₅₀ = 0.49 μM), but has poor activity against carbachol-induced, TRPC3-mediated calcium entry in TRPC3-transfected HEK293 cells (IC₅₀ = 18.46 μM).

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable