SML1605
OTX015
≥98% (HPLC)
동의어(들):
6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-, (6S)-, OTX-015
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C25H22ClN5O2S
CAS Number:
Molecular Weight:
491.99
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
white to light brown
solubility
DMSO: 20 mg/mL, clear
저장 온도
2-8°C
SMILES string
O=C(NC(C=C1)=CC=C1O)C[C@H]2C3=NN=C(C)N3C(SC(C)=C4C)=C4C(C5=CC=C(Cl)C=C5)=N2
InChI
1S/C25H22ClN5O2S/c1-13-14(2)34-25-22(13)23(16-4-6-17(26)7-5-16)28-20(24-30-29-15(3)31(24)25)12-21(33)27-18-8-10-19(32)11-9-18/h4-11,20,32H,12H2,1-3H3,(H,27,33)/t20-/m0/s1
InChI key
GNMUEVRJHCWKTO-FQEVSTJZSA-N
유전자 정보
human ... BRD2(6046), BRD3(8019), BRD4(23476), BRDT(676)
생화학적/생리학적 작용
It binds to bromodomain and extra-terminal domain (BET) proteins and inhibits their binding to the chromatin. This in turn prevents gene transcription. OTX015 has been shown to inhibit proliferation of cells in haematological malignancies.
OTX015 is a potent inhibitor of the BET bromodomain proteins 2, 3, and 4 (BRD2/3/4).
OTX015 is a potent inhibitor of the BET bromodomain proteins 2, 3, and 4.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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