SML1608

Besifloxacin hydrochloride

≥98% (HPLC)

• 동의어(들): 7-[-3-Aminoazepam-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
• 실험식(Hill 표기법): C₁₉H₂₁ClFN₃O₃ · HCl
• CAS Number: 1398566-43-2
• Molecular Weight: 430.30
• MDL number: MFCD23712955
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825494
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• 색상: white to light brown
• solubility: DMSO: 2 mg/mL, clear (warmed)
• 저장 온도: −20°C
• SMILES string: [H]Cl.OC(C1=CN(C2CC2)C3=C(Cl)C(N4CCCCC(N)C4)=C(F)C=C3C1=O)=O
• InChI: 1S/C19H21ClFN3O3.ClH/c20-15-16-12(18(25)13(19(26)27)9-24(16)11-4-5-11)7-14(21)17(15)23-6-2-1-3-10(22)8-23;/h7,9-11H,1-6,8,22H2,(H,26,27);1H
• InChI key: PMQBICKXAAKXAY-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

Besifloxacin is a broad spectrum fourth-generation fluoroquinolone antibiotic.

Besifloxacin is a broad spectrum fourth-generation fluoroquinolone antibiotic. Besifloxacin is effective against gram positive and negative, aerobic and anerobic bacteria. Fluoroquinolones stabilize DNA strand breaks created by DNA gyrase and topoisomerase IV by binding to the enzyme-DNA complex generating persistent, covalent enzyme–DNA adducts, inhibiting DNA synthesis. Besifloxacin inhibits both DNA gyrase and topoisomerase IV at nearly equal concentrations. It is used clinically primarily in the treatment of bacterial conjunctivitis.

Besifloxacin stops the production of pro-inflammatory cytokines in vitro.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable