SML2244

AC1903

≥98% (HPLC)

• 동의어(들): N-(2-Furanylmethyl)-1-(phenylmethyl)-1H-benzimidazol-2-amine
• 실험식(Hill 표기법): C₁₉H₁₇N₃O
• CAS Number: 831234-13-0
• Molecular Weight: 303.36
• MDL number: MFCD06609959
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: C12=CC=CC=C1N=C(NCC3=CC=CO3)N2CC4=CC=CC=C4
• InChI: 1S/C19H17N3O/c1-2-7-15(8-3-1)14-22-18-11-5-4-10-17(18)21-19(22)20-13-16-9-6-12-23-16/h1-12H,13-14H2,(H,20,21)
• InChI key: OECUWHDVQIITIS-UHFFFAOYSA-N

설명

애플리케이션

AC1903 has been used as a drug candidate in a high-throughput agar colony formation assay to identify its therapeutic efficiency against medulloblastoma.

생화학적/생리학적 작용

AC1903 is a specific inhibitor of TRPC5, the transient receptor potential canonical channel 5, a Ca²⁺ permeable nonselective cation channel highly expressed in brain and kidney. AC1903 did not inhibit TRPC4 or TRPC6 currents and showed no off-target effects in kinase profiling assays. It specifically blocked TRPC5 channel activity in glomeruli of proteinuric rats, suppressed severe proteinuria, showing a therapeutic benefit in a rat model of hypertensive proteinuric kidney disease.

Chronic administration of AC1903 averts the loss of podocytes in a transgenic rat model of focal segmental glomerulosclerosis (FSGS).

Specific inhibitor of TRPC5

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable