SML2587

AQ1 trifluoroacetic acid salt

≥98% (HPLC)

• 동의어(들): 2,2′-(9,10-dihydro-9,10-dioxo-1,5-anthracenediyl)bis[L-lysyl-β-alaninamide trifluoroacetic acid
• 실험식(Hill 표기법): C₃₂H₄₄N₈O₆ · xC₂HF₃O₂
• CAS Number: 1338367-84-2
• Molecular Weight: 636.74 (free base basis)
• UNSPSC 코드: 12352106
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: faint yellow to dark orange
• solubility: H₂O: 2 mg/mL, clear
• 저장 온도: −20°C

설명

생화학적/생리학적 작용

AQ1, an anthraquinone derivative, is a potent stabilizer of c-KIT G-quadruplexes (G4) that downregulates c-KIT mRNA and protein expression in human and canine cell lines. Also, AQ1 causes inhibition BCL2 gene expression in HGC27 and MCF7 cells. AQ1 inhibits proliferation of in varies human tumor cell lines including HCG27, MCF7 and imatinib resistant HMC1.2 cells.

potent stabilizer of c-KIT G-quadruplexes (G4) that downregulates c-KIT mRNA and protein expression; KIT transcriptional down-regulator

안전성 정보

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable