SML2953

MGR1

≥98% (HPLC)

• 동의어(들): 2,2-Dimethylpropanoic acid [(1,4,4a,9,9a,10-hexahydro-9,10-dioxo-1,4-ethanoanthracen-5-yl)oxy]methyl ester, JCHD precursor
• 실험식(Hill 표기법): C₂₂H₂₄O₅
• CAS Number: 2361529-46-4
• Molecular Weight: 368.42
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: O=C1C2C(C(C3=C1C=CC=C3OCOC(C(C)(C)C)=O)=O)C4C=CC2CC4

설명

생화학적/생리학적 작용

Effective reactive oxygen species (ROS) generator in live cells. Activated by esterases to form JCHD for superoxide generation from molecular oxygen.

MGR1 is an effective reactive oxygen species (ROS) generator in live cells (dosing range 2-100 μM). MGR1 is activated by intracellular esterases to form JCHD (5-hydroxy-1,4,4a,9a-tetrahydro-1,4-ethanoanthracene-9,10-dione), which in turn, facilitated by a proximal H-bonding hydroxyl group, undergoes keto-enol tautomerism for enhanced superoxide (O2•-) generation upon reacting with molecular oxygen (O2). MGR1, but not its inactive analog MGR2, upregulates cellular ROS, resulting in cell death when used at high concentrations (>5 μM; RAW264.7, THP1, HeLa, MCF7, A549).

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable